- Mike Henry - Cleveland Brown, Rallo Tubbs
- Sanaa Lathan - Donna Tubbs-Brown
- Jason Sudeikis - Holt Richter, Terry Kimple y Kenny West
- Will Forte - Cleveland Brown Jr.
- Kevin Michael Richardson - Federline Jones, Lester Krinklesac
- Reagan Gómez-Preston - Roberta Tubbs
- Seth Green - Chris Powell
- Alex Borstein - Tricia Takanawa, Lois Griffin, Bárbara
-Arianna Huffington -Arianna Huffington
-Jamie Kennedy -Robert
- Corey Holcomb - Kenny Loggins
- David Lynch - Gus
- Gilbert Gottfried - El guardián de la cripta
- Patrick Stewart - Él mismo