| Personaje | Actor |
|---|---|
| Jake Sully | Sam Worthington |
| Neytiri | Zoe Saldaña |
| Coronel Miles Quaritch | Esteban Lang |
| Dra. Gracia Agustín | Sigourney Weaver |
| Trudy Chacón | Michelle Rodríguez |
| Tsu'tey | Laz Alonso |
| Parker Selfridge | Juan Ribisi |
| Norma Spellman | Joel David Moore |
| Dr. Max Patel | Dileep Rao |
| Eytukan | Wes Studi |
| Mo'at | Libra CCH |